Issue 1, 2024

Dynamic experiments in flow accelerate reaction network definition in a complex hydrogenation using catalytic static mixers

Abstract

Kinetic screening, when conducted in batch or under steady state flow conditions, is time consuming. In this work we leverage transient flow experiments to investigate the hydrogenation of an aryl ketone in a gas–liquid flow reactor, catalyzed by catalytic static mixers and monitored using process analytical technologies. Ramping reactor parameters over time allowed the exploration of different residence times and temperatures in a single experiment, allowing rapid definition of the reaction network. Data analysis using a batch approximation approach and a plug flow reactor approach allowed parameterization of predictive reaction models. A Pd/Al2O3 catalyst performed ketone reduction, followed by dehydration to the ethylbenzene derivative. Conversely, Pt/Al2O3 and Ru/Al2O3 showed aromatic ring hydrogenation as the main reaction pathway, following ketone reduction. The developed workflow is likely to be highly applicable to other chemical systems and reaction types.

Graphical abstract: Dynamic experiments in flow accelerate reaction network definition in a complex hydrogenation using catalytic static mixers

Supplementary files

Article information

Article type
Paper
Submitted
25 Aug. 2023
Accepted
25 Sept. 2023
First published
29 Sept. 2023
This article is Open Access
Creative Commons BY-NC license

React. Chem. Eng., 2024,9, 132-138

Dynamic experiments in flow accelerate reaction network definition in a complex hydrogenation using catalytic static mixers

S. Martinuzzi, M. Tranninger, P. Sagmeister, M. Horn, J. D. Williams and C. O. Kappe, React. Chem. Eng., 2024, 9, 132 DOI: 10.1039/D3RE00451A

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