Issue 2, 2024

A multifunctional organophosphonic ligand-templated poly(polyoxotungstate) with potential in building a genosensor for thalassemia gene detection

Abstract

A novel PV–SbIII heteroatom-inserted poly(polyoxotungstate) (poly(POT)) [H2N(CH3)2]5Na11H9[(HEDATMPA)SbW15O50]{[PrW4O10][B-α-SbW9O33]2}·38H2O (1) was synthesized and is composed of an attractive [(HEDATMPA)SbW15O50]14− hybrid fragment and one sandwich-like PrIII-inserted [PrW4O10(B-α-SbW9O33)2]11− entity by using ethylenediamine tetramethylphosphoric acid (H8EDATMPA) with potential heteroatom sites and functional organic groups. Considering the advantages of poly(POT) clusters in storing and transferring electrons, we fabricated a 1-PEDOT (PEDOT = poly(3,4-ethylenedioxythiophene)) hybrid film, which was used as an electrode-modified material to construct a 1-based genosensor (GS) for detecting the β-thalassemia gene. Research results show that this 1-based GS demonstrates high specificity, outstanding antijamming ability and low detection limit for β-thalassemia gene detection. This work not only provides a novel and feasible preparative strategy to construct poly(POT) clusters, but also promisingly promotes the development of poly(POT)-based GSs.

Graphical abstract: A multifunctional organophosphonic ligand-templated poly(polyoxotungstate) with potential in building a genosensor for thalassemia gene detection

Supplementary files

Article information

Article type
Research Article
Submitted
20 Sept. 2023
Accepted
18 Nov. 2023
First published
21 Nov. 2023

Inorg. Chem. Front., 2024,11, 602-612

A multifunctional organophosphonic ligand-templated poly(polyoxotungstate) with potential in building a genosensor for thalassemia gene detection

W. Zhang, Z. Wang, M. Cao, D. Wang, L. Chen and J. Zhao, Inorg. Chem. Front., 2024, 11, 602 DOI: 10.1039/D3QI01916K

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