Issue 13, 2024

Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis

Abstract

Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable to target components or molecular processes within plaques, while carrying diagnostic and therapeutic agents. However, the number of biomarkers available to target this disease is limited. This study investigated the use of sphingomyelin-based nanomicelles triggered by sphingomyelinase (SMase) in atherosclerotic plaques. Accumulation of iron oxide-based nanomicelles in the plaque was demonstrated by fluorescence, MR imaging and electron microscopy. These findings demonstrate the possibility of utilising SMase as a mechanism to retain nanoprobes within plaques, thus opening up possibilities for future therapeutic interventions.

Graphical abstract: Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis

Article information

Article type
Paper
Submitted
20 Dec. 2023
Accepted
23 Febr. 2024
First published
26 Febr. 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale, 2024,16, 6477-6487

Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis

M. Muñoz-Hernando, P. Nogales, I. Fernández-Barahona, J. Ruiz-Cabello, J. F. Bentzon and F. Herranz, Nanoscale, 2024, 16, 6477 DOI: 10.1039/D3NR06507C

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