Issue 2, 2024

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Abstract

Silica nanoparticles have emerged as promising candidates in the field of nanomedicine due to their remarkable versatility and customizable properties. However, concerns about their potential toxicity in healthy tissues and organs have hindered their widespread clinical translation. To address this challenge, significant attention has been directed toward a specific subset of silica nanoparticles, namely degradable silica nanoparticles, primarily because of their excellent biocompatibility and responsive biodegradability. In this review, we provide a comprehensive understanding of degradable silica nanoparticles, categorizing them into two distinct groups: inorganic species-doped and organic moiety-doped silica nanoparticles based on their framework components. Next, the recent progress of tumor microenvironment (TME)-responsive degradable silica nanoparticles for precision theranostic applications is summarized in detail. Finally, current bottlenecks and future opportunities of theranostic nanomedicines based on degradable silica nanoparticles in clinical applications are also outlined and discussed. The aim of this comprehensive review is to shed light on the potential of degradable silica nanoparticles in addressing current challenges in nanomedicine, offering insights into their design, applications in tumor diagnosis and treatment, and paving the way for future advancements in clinical theranostic nanomedicines.

Graphical abstract: Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

Article information

Article type
Review Article
Submitted
06 Sept. 2023
Accepted
28 Nov. 2023
First published
29 Nov. 2023

Nanoscale Horiz., 2024,9, 186-214

Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications

J. Zhang, K. Tang, Z. Liu, Z. Zhang, S. Duan, H. Wang, H. Yang, D. Yang and W. Fan, Nanoscale Horiz., 2024, 9, 186 DOI: 10.1039/D3NH00388D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements