Issue 15, 2024

Revolutionizing cancer therapy using tetrahedral DNA nanostructures as intelligent drug delivery systems

Abstract

DNA nanostructures have surfaced as intriguing entities with vast potential in biomedicine, notably in the drug delivery area. Tetrahedral DNA nanostructures (TDNs) have received worldwide attention from among an array of different DNA nanostructures due to their extraordinary stability, great biocompatibility, and ease of functionalization. TDNs could be readily synthesized, making them attractive carriers for chemotherapeutic medicines, nucleic acid therapeutics, and imaging probes. Their varied uses encompass medication delivery, molecular diagnostics, biological imaging, and theranostics. This review extensively highlights the mechanisms of functional modification of TDNs and their applications in cancer therapy. Additionally, it discusses critical concerns and unanswered problems that require attention to increase the future application of TDNs in developing cancer treatment.

Graphical abstract: Revolutionizing cancer therapy using tetrahedral DNA nanostructures as intelligent drug delivery systems

Article information

Article type
Review Article
Submitted
17 Febr. 2024
Accepted
24 Maijs 2024
First published
28 Maijs 2024
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2024,6, 3714-3732

Revolutionizing cancer therapy using tetrahedral DNA nanostructures as intelligent drug delivery systems

A. Sharma, P. Vaswani and D. Bhatia, Nanoscale Adv., 2024, 6, 3714 DOI: 10.1039/D4NA00145A

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