Issue 3, 2024

Mn(iii), Fe(iii) and Zn(ii)-serum albumin as innovative multicolour contrast agents for photoacoustic imaging

Abstract

Here we propose innovative photoacoustic imaging (PAI) contrast agents, based on the loading of Mn(III)-, Fe(III)- or Zn(II)-protoporphyrin IX in serum albumin. These systems show different absorption wavelengths, opening the way to multicolor PA imaging. They were characterized in vitro for assessing stability, biocompatibility, and their optical and contrastographic properties. Finally, a proof of concept in vivo study was carried out in breast cancer bearing mice, to evaluate its effectiveness for cancer imaging.

Graphical abstract: Mn(iii), Fe(iii) and Zn(ii)-serum albumin as innovative multicolour contrast agents for photoacoustic imaging

Supplementary files

Article information

Article type
Communication
Submitted
02 Okt. 2023
Accepted
22 Dec. 2023
First published
24 Dec. 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2024,6, 777-781

Mn(III), Fe(III) and Zn(II)-serum albumin as innovative multicolour contrast agents for photoacoustic imaging

E. Di Gregorio, A. Scarciglia, A. Amaolo and G. Ferrauto, Nanoscale Adv., 2024, 6, 777 DOI: 10.1039/D3NA00843F

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