Issue 1, 2024

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

Abstract

Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial metalloenzymes that recapitulate the catalytic activity of enzymes can not only circumvent the enzymatic fragility but also bring versatile functions into practice. Among them, metal–organic frameworks (MOFs) featuring diverse and site-isolated metal sites and supramolecular structures have emerged as promising candidates for metalloenzymes to move toward unparalleled properties and behaviour of enzymes. In this review, we systematically summarize the significant advances in MOF-based metalloenzyme mimics with a special emphasis on active pocket engineering at the atomic level, including primary catalytic sites and secondary coordination spheres. Then, the deep understanding of catalytic mechanisms and their advanced applications are discussed. Finally, a perspective on this emerging frontier research is provided to advance bioinspired catalysis.

Graphical abstract: Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

Article information

Article type
Review Article
Submitted
13 Sept. 2023
First published
29 Nov. 2023

Chem. Soc. Rev., 2024,53, 137-162

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

W. Xu, Y. Wu, W. Gu, D. Du, Y. Lin and C. Zhu, Chem. Soc. Rev., 2024, 53, 137 DOI: 10.1039/D3CS00767G

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