Issue 72, 2024

Supramolecular chemical biology: designed receptors and dynamic chemical systems

Abstract

Supramolecular chemistry focuses on the study of species joined by non-covalent interactions, and therefore on dynamic and relatively ill-defined structures. Despite being a well-developed field, it has to face important challenges when dealing with the selective recognition of biomolecules in highly competitive biomimetic media. However, supramolecular interactions reside at the core of chemical biology systems, since many processes in nature are governed by weak, non-covalent, strongly dynamic contacts. Therefore, there is a natural connection between these two research fields, which are not frequently related or share interests. In this feature article, I will highlight our most recent results in the molecular recognition of biologically relevant species, following different conceptual approaches from the most conventional design of elaborated receptors to the less popular dynamic combinatorial chemistry methodology. Selected illustrative examples from other groups will be also included. The discussion has been focused mainly on systems with potential biomedical applications.

Graphical abstract: Supramolecular chemical biology: designed receptors and dynamic chemical systems

Article information

Article type
Feature Article
Submitted
27 Jūn. 2024
Accepted
26 Jūl. 2024
First published
27 Jūl. 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 9692-9703

Supramolecular chemical biology: designed receptors and dynamic chemical systems

I. Alfonso, Chem. Commun., 2024, 60, 9692 DOI: 10.1039/D4CC03163F

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