Issue 51, 2024

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Abstract

Pyroptosis is regarded as a promising strategy to modulate tumor immune microenvironments for anticancer therapy. Although pyroptosis inducers have been extensively explored in the biomedical field, their drug resistance, off-targeting capacity, and adverse effects do not fulfill the growing demands of therapy. Nowadays, metal–organic frameworks (MOFs) with unique structures and facile synthesis/functionalization characteristics have shown great potential in anticancer therapy. The flexible choices of metal ions and ligands endow MOFs with inherent anti-cancer efficiency, whereas the porous structures in MOFs make them ideal vehicles for delivering various chemodrug-based pyroptosis inducers. In this review, we provide the latest advances in MOF-based materials to evoke pyroptosis and give a brief but comprehensive review of the different types of MOFs for pyroptosis-mediated cancer therapy. Finally, we also discuss the current challenges of MOF-based pyroptosis inducers and their future prospects in this field.

Graphical abstract: Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Article information

Article type
Feature Article
Submitted
30 Apr. 2024
Accepted
03 Jūn. 2024
First published
04 Jūn. 2024

Chem. Commun., 2024,60, 6476-6487

Metal–organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Y. Dou, Y. Wang, S. Tian, Q. Song, Y. Deng, Z. Zhang, P. Chen and Y. Sun, Chem. Commun., 2024, 60, 6476 DOI: 10.1039/D4CC02084G

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