Issue 41, 2024

Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(i)-catalyzed C–H alkenylation

Abstract

The late-stage fluorescent labeling of structurally complex peptides bears immense potential for molecular imaging. Herein, we report on a manganese(I)-catalyzed peptide C–H alkenylation under exceedingly mild conditions with natural fluorophores as coumarin- and chromone-derivatives. The robustness and efficiency of the manganese(I) catalysis regime was reflected by a broad functional group tolerance and low catalyst loading in a resource- and atom-economical fashion.

Graphical abstract: Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(i)-catalyzed C–H alkenylation

Supplementary files

Article information

Article type
Communication
Submitted
24 Janv. 2024
Accepted
19 Apr. 2024
First published
22 Apr. 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024,60, 5423-5426

Fluorescent coumarin-alkynes for labeling of amino acids and peptides via manganese(I)-catalyzed C–H alkenylation

A. Kopp, T. Oyama and L. Ackermann, Chem. Commun., 2024, 60, 5423 DOI: 10.1039/D4CC00361F

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