Issue 1, 2024

Alternative protein encapsulation with MOFs: overcoming the elusive mineralization of HKUST-1 in water

Abstract

Protein encapsulation by in situ formation of MOFs is a valuable strategy to immobilise and protect these bioentities. However the required biocompatible conditions limits the scope of MOFs under investigation, particularly in the case of hydrolytically unstable MOFs such as HKUST-1. We report alternative synthetic procedures to obtain protein@HKUST-1 biocomposites from related Cu-BTC dense biocomposites. pH dependent dense phase precursors are first obtained and their transformations into HKUST-1 are characterized. Encapsulation efficiency is affected by the protein's nature, and can be modulated by the sequential or simultaneous addition of MOF precursors.

Graphical abstract: Alternative protein encapsulation with MOFs: overcoming the elusive mineralization of HKUST-1 in water

Supplementary files

Article information

Article type
Communication
Submitted
01 Sept. 2023
Accepted
08 Nov. 2023
First published
17 Nov. 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 51-54

Alternative protein encapsulation with MOFs: overcoming the elusive mineralization of HKUST-1 in water

J. C. Díaz and M. Giménez-Marqués, Chem. Commun., 2024, 60, 51 DOI: 10.1039/D3CC04320G

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