Issue 3, 2024

Injectable cell-laden silk acid hydrogel

Abstract

This study presents an injectable cell-laden hydrogel system based on silk acid, a carboxylated derivative of natural silk fibroin, which exhibits promising applications in biomedicine. The hydrogel is produced under physiological conditions (37 °C and pH 7.4) via physical crosslinking. Notably, the hydrogel demonstrates remarkable cytocompatibility, enabling efficient cell encapsulation, and exhibits good injectability. These promising results strongly indicate the potential of silk acid hydrogel for transformative applications, including 3D cell culture, targeted cell delivery, and tissue engineering.

Graphical abstract: Injectable cell-laden silk acid hydrogel

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug. 2023
Accepted
29 Nov. 2023
First published
29 Nov. 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2024,60, 316-319

Injectable cell-laden silk acid hydrogel

Z. Sun, H. Liu, D. Dai, H. Lyu, R. Huang, W. Wang and C. Guo, Chem. Commun., 2024, 60, 316 DOI: 10.1039/D3CC04280D

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