Issue 25, 2024

Rapid differentiation of xylazine metabolites using SLIM IM-MS

Abstract

Xylazine represents an increased threat to the recreational drug market. In this study, we present a rapid strategy for identifying xylazine and differentiating its common isomeric metabolites using Structures for Lossless Ion Manipulations (SLIM) ion mobility coupled to high-resolution/tandem mass spectrometry (IM-HRMS/MS). Chemical derivatization using dansyl chloride also assisted with separations and led to identification of resolvable reaction product atropisomers.

Graphical abstract: Rapid differentiation of xylazine metabolites using SLIM IM-MS

Supplementary files

Article information

Article type
Communication
Submitted
30 Apr. 2024
Accepted
03 Jūn. 2024
First published
05 Jūn. 2024
This article is Open Access
Creative Commons BY license

Anal. Methods, 2024,16, 4041-4044

Rapid differentiation of xylazine metabolites using SLIM IM-MS

R. Aderorho, S. W. Lucas and C. D. Chouinard, Anal. Methods, 2024, 16, 4041 DOI: 10.1039/D4AY00801D

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