Issue 44, 2023

Rational design of copper(i)-doped metal–organic frameworks as dual-functional nanocarriers for combined chemo–chemodynamic therapy

Abstract

Combination therapies are an increasingly important part of the antitumor medicine armamentarium. However, developing desirable nanomaterials for combination therapies is still a great challenge. Herein, a biocompatible Cu(I)-doped metal–organic framework (MOF) (denoted as CuZn-ZIF) is designed as a novel dual-functional nanocarrier. Doxorubicin molecules are covalently bound to the surface of the CuZn-ZIF and released by the cleavage of chemical bonds in an acidic environment, demonstrating the capacity of controlled drug release. More importantly, CuZn-ZIF nanocarriers can simultaneously play the role of nanocatalysts, capable of catalyzing H2O2 into a highly reactive intracellular toxic hydroxyl radical (˙OH). An in vivo study reveals that nanoparticles exhibit high antitumor efficacy through the combined performance of DOX and Cu(I), proving the great potential of this copper(I)-based MOF for combined chemo-chemotherapy to improve therapeutic efficacy.

Graphical abstract: Rational design of copper(i)-doped metal–organic frameworks as dual-functional nanocarriers for combined chemo–chemodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
16 Aug. 2023
Accepted
16 Okt. 2023
First published
19 Okt. 2023

J. Mater. Chem. B, 2023,11, 10632-10639

Rational design of copper(I)-doped metal–organic frameworks as dual-functional nanocarriers for combined chemo–chemodynamic therapy

L. Yao, B. Chen, H. Wu, Y. Cui and G. Qian, J. Mater. Chem. B, 2023, 11, 10632 DOI: 10.1039/D3TB01869E

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