Issue 20, 2023

The revelation of glucose adsorption mechanisms on hierarchical metal–organic frameworks using a surface plasmon resonance sensor

Abstract

The gold layer on the surface plasmon resonance (SPR) sensor chip cannot detect small molecules, such as glucose without the use of specific receptors. Metal–organic frameworks (MOFs) are useful in biosensing technologies for capturing and co-localizing enzymes and receptors with the target biomolecule. In many previous studies, the properties of the MOFs were often ignored, with these studies focusing on the selection of appropriate receptors. To take advantage of the unique properties of MOFs in biosensors, one must also consider the technique and transducer used because these aspects will strongly influence the detection mechanism. In this work, we have investigated for the first time, the applications of hierarchical metal-BDC (M-BDC) MOFs for glucose detection using the SPR technique without the use of specific receptors. The underlying interactions and adsorption mechanisms were analyzed using adsorption isotherm and kinetic models. The sensing measurements show that the SPR chips functionalized with M-BDC MOFs exhibit higher sensitivity and lower limit of detection (LOD). Specifically, the sensitivity follows the order of Zr-BDC > Cu-BDC > Mn-BDC > Ni-BDC > bare Au SPR chips with the LOD in the order of Zr-BDC < Mn-BDC < Ni-BDC < Cu-BDC < bare Au SPR chips. The selectivity test results reveal that Zr-BDC exhibits a decent selectivity to glucose in the presence of other interfering compounds, such as ascorbic acid, uric acid, maltose, and urea. These results demonstrate the promising potential of MOFs for SPR biosensing.

Graphical abstract: The revelation of glucose adsorption mechanisms on hierarchical metal–organic frameworks using a surface plasmon resonance sensor

Supplementary files

Article information

Article type
Paper
Submitted
22 Janv. 2023
Accepted
12 Marts 2023
First published
28 Marts 2023

J. Mater. Chem. B, 2023,11, 4428-4444

The revelation of glucose adsorption mechanisms on hierarchical metal–organic frameworks using a surface plasmon resonance sensor

G. Gumilar, S. Chowdhury, G. Shukri, A. Patah, N. Nugraha, J. Henzie, I. Anshori, Y. V. Kaneti and B. Yuliarto, J. Mater. Chem. B, 2023, 11, 4428 DOI: 10.1039/D3TB00138E

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