Issue 12, 2023

Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery

Abstract

Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX·HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.

Graphical abstract: Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
09 Dec. 2022
Accepted
03 Febr. 2023
First published
03 Febr. 2023

J. Mater. Chem. B, 2023,11, 2631-2637

Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery

C. Cheng, J. Ma, J. Zhao, H. Lu, Y. Liu, C. He, M. Lu, X. Yin, J. Li and M. Ding, J. Mater. Chem. B, 2023, 11, 2631 DOI: 10.1039/D2TB02686D

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