Issue 8, 2023

Post-imprinting modification: electrochemical and scanning electrochemical microscopy studies of a semi-covalently surface imprinted polymer

Abstract

Herein we described a post-imprinting modification of the imprinted molecular cavities for electrochemical sensing of a target protein. Imprinted molecular cavities were generated by following the semi-covalent surface imprinting approach. These mesoporous cavities were modified with a ferrocene ‘electrochemical’ tracer for electrochemical transduction of the target protein recognition. Electrochemical sensors prepared after post-imprinting modification showed a linear response in the concentration range of 0.5 to 50 μM. Chemosensors fabricated based on capacitive impedimetric transduction demonstrated that imprinted molecular cavities without post-imprinting modification showed better selectivity. Scanning electrochemical microscopy (SECM) was used for the surface characterization of imprinted molecular cavities modified with ferrocene electrochemical tracers. SECM analysis performed in the feedback mode monitor changes in the surface state of the ferrocene-modified polymer film. The kinetics of the mediator regeneration was almost 1.8 times higher on the non-imprinted surface versus the post-imprinting modified molecular imprinted polymer.

Graphical abstract: Post-imprinting modification: electrochemical and scanning electrochemical microscopy studies of a semi-covalently surface imprinted polymer

Supplementary files

Article information

Article type
Paper
Submitted
04 Okt. 2022
Accepted
29 Dec. 2022
First published
25 Janv. 2023
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2023,11, 1659-1669

Post-imprinting modification: electrochemical and scanning electrochemical microscopy studies of a semi-covalently surface imprinted polymer

J. Kalecki, M. Cieplak, Z. Iskierko, J. Piechowska, W. Nogala, F. D’Souza and P. S. Sharma, J. Mater. Chem. B, 2023, 11, 1659 DOI: 10.1039/D2TB02116A

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