Issue 48, 2023

Improving the potential of paraCEST through magnetic-coupling induced line sharpening

Abstract

Magnetic coupling between paramagnetic centers is a crucial phenomenon in the design of efficient MRI contrast agents. In this study, we investigate the paraCEST properties and magnetic coupling effects of a novel homodinuclear Ni(II) complex, 1, containing a Robson type macrocyclic ligand. A thorough analysis of the complex's electronic and magnetic properties revealed that the magnetic coupling effect reduces the transverse relaxation rate and enhances the sharpness of the proton resonances, leading to enhanced CEST efficiency. This novel mechanism, which we coined “magnetic-coupling induced line sharpening” (MILS), can be crucial for optimizing the performance of paramagnetic metal complexes in paraCEST imaging. Moreover, magnetic coupling plays a critical role in the relaxation properties of homodinuclear complexes. Our study not only paves the way for the creation of advanced paraCEST agents with enhanced CEST capabilities and sensitivity but also provides valuable guidance for the design of other MRI contrast agents utilizing dinuclear metal complexes.

Graphical abstract: Improving the potential of paraCEST through magnetic-coupling induced line sharpening

Supplementary files

Article information

Article type
Edge Article
Submitted
09 Sept. 2023
Accepted
17 Nov. 2023
First published
21 Nov. 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 14157-14165

Improving the potential of paraCEST through magnetic-coupling induced line sharpening

X. Guo, L. Zhang, J. Hu, B. Szilágyi, M. Yu, S. Chen, G. Tircsó, X. Zhou and J. Tao, Chem. Sci., 2023, 14, 14157 DOI: 10.1039/D3SC04770A

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