Issue 22, 2023

Advancement of vinylene carbonate as a coupling partner in metal-catalyzed C–H functionalization

Abstract

Organic carbonates are important and valuable building blocks in synthetic chemistry. Among them, vinylene carbonate (VC) has emerged as a promising coupling partner to participate in various attractive C–H conversions and implement an increasing number of novel reactions. In this review, we provide a summary of the advancement achieved in metal-catalyzed C–H functionalization using VC as a popular coupling partner. We systematically discuss different reaction forms, including acylmethylation, [n + 2] cyclization, [n + 1] cyclization, [n + 2 + 1] cyclization, and [n + 3] cyclization. Diverse reaction mechanisms are demonstrated to inspire further research in this promising field of organic carbonates.

Graphical abstract: Advancement of vinylene carbonate as a coupling partner in metal-catalyzed C–H functionalization

Article information

Article type
Review Article
Submitted
03 Aug. 2023
Accepted
24 Sept. 2023
First published
25 Sept. 2023

Org. Chem. Front., 2023,10, 5717-5734

Advancement of vinylene carbonate as a coupling partner in metal-catalyzed C–H functionalization

Y. Ge, Q. Yan and J. Nan, Org. Chem. Front., 2023, 10, 5717 DOI: 10.1039/D3QO01227A

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