Issue 11, 2023

Recent advances in the cyclization reactions of pyridinium 1,n-zwitterions (n = 4 and 5): scope and mechanism

Abstract

Nitrogen- and sulfur-containing heterocyclic compounds widely exist in bioactive natural products and drug molecules with unique bioactivity. In the past few decades, great efforts have been devoted to developing convenient and efficient strategies for the synthesis of these compounds. Pyridinium zwitterions with unique reactivity play a significant role in the construction of nitrogen- and sulfur-containing heterocycles. In recent years, pyridinium zwitterions have been extensively used in cyclization reactions for the synthesis of novel heterocyclic compounds. This review summarizes the recent advances in cyclization reactions involving pyridinium 1,n-zwitterions (n = 4 and 5) and highlights the applications of these zwitterions in the efficient construction of heterocycles.

Graphical abstract: Recent advances in the cyclization reactions of pyridinium 1,n-zwitterions (n = 4 and 5): scope and mechanism

Article information

Article type
Review Article
Submitted
14 Febr. 2023
Accepted
19 Apr. 2023
First published
20 Apr. 2023

Org. Chem. Front., 2023,10, 2813-2829

Recent advances in the cyclization reactions of pyridinium 1,n-zwitterions (n = 4 and 5): scope and mechanism

J. Huang, L. Zhang and X. Meng, Org. Chem. Front., 2023, 10, 2813 DOI: 10.1039/D3QO00228D

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