Issue 31, 2023

Protein redox by a piezoelectric acousto-nanodevice

Abstract

Protein redox is responsible for many crucial biological processes; thus, the ability to modulate the redox proteins through external stimuli presents a unique opportunity to tune the system. In this work, we present an acousto-nanodevice that is capable of oxidizing redox protein under ultrasonic irradiation via surface-engineered barium titanate (BTO) nanoparticles with a gold half-coating. Using cytochrome c as the model protein, we demonstrate nanodevice-mediated protein oxidation. BINased on our experimental observations, we reveal that the electron transfer occurs in one direction due to the alternating electrical polarization of BTO under ultrasound. Such unique unidirectional electron transfer is enabled by modulating the work function of the gold surface with respect to the redox center. The new class of ultrasonically powered nano-sized protein redox agents could be a modulator for biological processes with high selectivity and deeper treatment sites.

Graphical abstract: Protein redox by a piezoelectric acousto-nanodevice

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr. 2023
Accepted
07 Jūl. 2023
First published
12 Jūl. 2023

Nanoscale, 2023,15, 12889-12893

Author version available

Protein redox by a piezoelectric acousto-nanodevice

S. Selvarajan, H. Shim, E. Byun, A. Kim and S. H. Song, Nanoscale, 2023, 15, 12889 DOI: 10.1039/D3NR01523H

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