Issue 1, 2023

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease that brings about enormous economic pressure to families and society. Inhibiting abnormal aggregation of Aβ and accelerating the dissociation of aggregates is treated as an effective method to prevent and treat AD. Recently, nanomaterials have been applied in AD treatment due to their excellent physicochemical properties and drug activity. As a drug delivery platform or inhibitor, various excellent nanomaterials have exhibited potential in inhibiting Aβ fibrillation, disaggregating, and clearing mature amyloid plaques by enhancing the performance of drugs. This review comprehensively summarizes the advantages and disadvantages of nanomaterials in modulating amyloid aggregation and AD treatment. The design of various functional nanomaterials is discussed, and the strategies for improved properties toward AD treatment are analyzed. Finally, the challenges faced by nanomaterials with different dimensions in AD-related amyloid aggregate modulation are expounded, and the prospects of nanomaterials are proposed.

Graphical abstract: Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

Article information

Article type
Review Article
Submitted
14 Sept. 2022
Accepted
15 Nov. 2022
First published
21 Nov. 2022
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 46-80

Advanced nanomaterials for modulating Alzheimer's related amyloid aggregation

X. Shao, C. Yan, C. Wang, C. Wang, Y. Cao, Y. Zhou, P. Guan, X. Hu, W. Zhu and S. Ding, Nanoscale Adv., 2023, 5, 46 DOI: 10.1039/D2NA00625A

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