Issue 21, 2023

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

Abstract

Ischaemic stroke (IS) is the second most common cause of death worldwide. Traditional treatment strategies, including blood flow recanalization therapy and neuroprotective drugs, have reduced safety and effectiveness due to their lack of targeting and inability to penetrate the blood–brain barrier (BBB). Targeted nanoparticles (NPs) can improve BBB penetration and brain targeting by changing their composition and structure, which can integrate a variety of treatment components to match the complex pathological process of IS. In this review, we describe recent advances in IS therapy, specifically in the prevention, detection, and treatment of IS, by using targeted NPs, presenting basic knowledge and possible therapeutic targets to highlight their potential for early treatment in the clinic.

Graphical abstract: Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

Article information

Article type
Review Article
Submitted
27 Jūl. 2023
Accepted
29 Sept. 2023
First published
30 Sept. 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2023,4, 5003-5017

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

X. Li, Q. Wang, Q. Fang, J. Xu, B. Han, Y. Chen, W. Yao, S. Ye and B. Wang, Mater. Adv., 2023, 4, 5003 DOI: 10.1039/D3MA00472D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements