Issue 5, 2023

Advancements in bacteriophage therapies and delivery for bacterial infection

Abstract

Having co-evolved with bacteria over hundreds of millions of years, bacteriophage are effective killers of specific bacterial hosts. Therefore, phage therapies for infection are a promising treatment avenue, can provide a solution for antibiotic resistant bacterial infections, and have specified targeting of infectious bacteria while allowing the natural microbiome to survive which systemic antibiotics often wipe out. Many phages have well studied genomes that can be modified to change target, widen target range, or change mode of action of killing bacterial hosts. Phage delivery can also be designed to increase efficacy of treatment, including encapsulation and delivery via biopolymers. Increased research into phage potential for therapies can allow new avenues to develop to treat a larger range of infections.

Graphical abstract: Advancements in bacteriophage therapies and delivery for bacterial infection

Article information

Article type
Review Article
Submitted
14 Okt. 2022
Accepted
25 Janv. 2023
First published
31 Janv. 2023
This article is Open Access
Creative Commons BY license

Mater. Adv., 2023,4, 1249-1257

Advancements in bacteriophage therapies and delivery for bacterial infection

H. A. Durr and N. D. Leipzig, Mater. Adv., 2023, 4, 1249 DOI: 10.1039/D2MA00980C

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