Issue 5, 2023

Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

Abstract

Nanoparticle systems are functional carriers that can be used in the cancer therapy field for the delivery of a variety of hydrophobic and/or hydrophilic drugs. Recently, the advent of microfluidic platforms represents an advanced approach to the development of new nanoparticle-based drug delivery systems. Particularly, microfluidics can simplify the design of new nanoparticle-based systems with tunable physicochemical properties such as size, size distribution and morphology, ensuring high batch-to-batch reproducibility and consequently, an enhanced therapeutic effect in vitro and in vivo. In this perspective, we present accurate state-of-the-art microfluidic platforms focusing on the fabrication of polymer-based, lipid-based, lipid/polymer-based, inorganic-based and metal-based nanoparticles for biomedical applications.

Graphical abstract: Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

Article information

Article type
Perspective
Submitted
05 Okt. 2022
Accepted
28 Nov. 2022
First published
17 Janv. 2023
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2023,23, 1389-1409

Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy

A. Fabozzi, F. Della Sala, M. di Gennaro, M. Barretta, G. Longobardo, N. Solimando, M. Pagliuca and A. Borzacchiello, Lab Chip, 2023, 23, 1389 DOI: 10.1039/D2LC00933A

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