Issue 5, 2023

Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models

Abstract

Organoids/organs-on-a-chip open up new frontiers for basic and clinical research of intestinal diseases. Species-specific differences hinder research on animal models, while organoids are emerging as powerful tools due to self-organization from stem cells and the reproduction of the functional properties in vivo. Organs-on-a-chip is also accelerating the process of faithfully mimicking the intestinal microenvironment. And by combining organoids and organ-on-a-chip technologies, they further are expected to serve as innovative preclinical tools and could outperform traditional cell culture models or animal models in the future. Above all, organoids/organs-on-a-chip with other strategies like genome editing, 3D printing, and organoid biobanks contribute to modeling intestinal homeostasis and disease. Here, the current challenges and future trends in intestinal pathophysiological models will be summarized.

Graphical abstract: Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models

Article information

Article type
Critical Review
Submitted
30 Aug. 2022
Accepted
15 Nov. 2022
First published
16 Janv. 2023

Lab Chip, 2023,23, 1192-1212

Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models

L. Wu, Y. Ai, R. Xie, J. Xiong, Y. Wang and Q. Liang, Lab Chip, 2023, 23, 1192 DOI: 10.1039/D2LC00804A

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