Issue 2, 2023

Multivalent glycosystems for human lectins

Abstract

Human lectins are involved in a wide variety of biological processes, both physiological and pathological, which have attracted the interest of the scientific community working in the glycoscience field. Multivalent glycosystems have been employed as useful tools to understand carbohydrate–lectin binding processes as well as for biomedical applications. The review shows the different scaffolds designed for a multivalent presentation of sugars and their corresponding binding studies to lectins and in some cases, their biological activities. We summarise this research by organizing based on lectin types to highlight the progression in this active field. The paper provides an overall picture of how these contributions have furnished relevant information on this topic to help in understanding and participate in these carbohydrate–lectin interactions.

Graphical abstract: Multivalent glycosystems for human lectins

Article information

Article type
Review Article
Submitted
30 Aug. 2022
First published
22 Dec. 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2023,52, 536-572

Multivalent glycosystems for human lectins

M. Martínez-Bailén, J. Rojo and J. Ramos-Soriano, Chem. Soc. Rev., 2023, 52, 536 DOI: 10.1039/D2CS00736C

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