Issue 32, 2023

Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

Abstract

Multiple studies have shown that the activity of alkaline phosphatase (AP) increases during Alzheimer's disease (AD). In this paper, using UV-Visible spectroscopy, we show that this increase in activity is due to its interaction with key components of AD such as amyloid β peptide and acetylcholinesterase. Activity increase also occurs due to high concentrations of acetylcholine and choline. These conditions are present in AD or could occur due to drugs used for treating AD.

Graphical abstract: Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

Supplementary files

Article information

Article type
Communication
Submitted
31 Marts 2023
Accepted
28 Jūl. 2023
First published
28 Jūl. 2023

Phys. Chem. Chem. Phys., 2023,25, 21149-21153

Author version available

Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

A. Bhide and A. Sen, Phys. Chem. Chem. Phys., 2023, 25, 21149 DOI: 10.1039/D3CP01480K

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