Issue 36, 2023

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

Abstract

Osteoarthritis caused by articular cartilage defects is a particularly common orthopedic disease that can involve the entire joint, causing great pain to its sufferers. A global patient population of approximately 250 million people has an increasing demand for new therapies with excellent results, and tissue engineering scaffolds have been proposed as a potential strategy for the repair and reconstruction of cartilage defects. The precise control and high flexibility of 3D printing provide a platform for subversive innovation. In this perspective, cartilage tissue engineering (CTE) scaffolds manufactured using different biomaterials are summarized from the perspective of 3D printing strategies, the bionic structure strategies and special functional designs are classified and discussed, and the advantages and limitations of these CTE scaffold preparation strategies are analyzed in detail. Finally, the application prospect and challenges of 3D printed CTE scaffolds are discussed, providing enlightening insights for their current research.

Graphical abstract: From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

Article information

Article type
Perspective
Submitted
28 Febr. 2023
Accepted
19 Aug. 2023
First published
25 Aug. 2023
This article is Open Access
Creative Commons BY-NC license

Phys. Chem. Chem. Phys., 2023,25, 24244-24263

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

H. Zhang, M. Wang, R. Wu, J. Guo, A. Sun, Z. Li, R. Ye, G. Xu and Y. Cheng, Phys. Chem. Chem. Phys., 2023, 25, 24244 DOI: 10.1039/D3CP00921A

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