Issue 84, 2023

Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers

Abstract

The reductive coupling of dienol ethers with N-tosylimines catalyzed by Ni(0) in the presence of a VAPOL-derived phosphoramidite ligand follows an unprecedented regiochemical course; it furnishes syn-configured 1,2-aminoalcohol derivatives in good chemical yields with up to 94% ee.

Graphical abstract: Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers

Supplementary files

Article information

Article type
Communication
Submitted
15 Sept. 2023
Accepted
28 Sept. 2023
First published
28 Sept. 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 12613-12616

Aminoalcohol derivatives by nickel-catalyzed enantioselective coupling of imines and dienol ethers

J. Y. Kim, T. Q. Davies and A. Fürstner, Chem. Commun., 2023, 59, 12613 DOI: 10.1039/D3CC04582J

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