Issue 88, 2023

High-order framework nucleic acid for targeted-delivery of antisense peptide nucleic acids to overcome drug resistance

Abstract

A sophisticated high-order framework nucleic acid (FNA) was engineered for the targeted delivery and responsive release of environment tolerant antisense peptide nucleic acids (asPNAs). The dendritic FNA-asPNAs system was constructed via simple one-pot modular assembly and demonstrated a good synergistic effect with chemotherapy on drug resistant cancer cells.

Graphical abstract: High-order framework nucleic acid for targeted-delivery of antisense peptide nucleic acids to overcome drug resistance

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug. 2023
Accepted
12 Okt. 2023
First published
13 Okt. 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 13223-13226

High-order framework nucleic acid for targeted-delivery of antisense peptide nucleic acids to overcome drug resistance

S. Xing, X. Lan, J. Zhang, M. Li and B. Wang, Chem. Commun., 2023, 59, 13223 DOI: 10.1039/D3CC04298G

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