Issue 79, 2023

Deamination-triggered exponential signal amplification for chemiluminescent detection of cytosine deaminase at the single-cell level

Abstract

We construct a sensitive chemiluminescent biosensor for sensitive detection of cytosine deaminase APOBEC3A based on deamination-triggered exponential signal amplification. This biosensor displays good specificity and high sensitivity, and it can screen APOBEC3A inhibitors and measure endogenous APOBEC3A at the single-cell level, with prospective applications in disease diagnostics and therapy.

Graphical abstract: Deamination-triggered exponential signal amplification for chemiluminescent detection of cytosine deaminase at the single-cell level

Supplementary files

Article information

Article type
Communication
Submitted
21 Aug. 2023
Accepted
11 Sept. 2023
First published
11 Sept. 2023

Chem. Commun., 2023,59, 11807-11810

Deamination-triggered exponential signal amplification for chemiluminescent detection of cytosine deaminase at the single-cell level

W. Liu, H. Li, X. Zou, Q. Liu, F. Ma and C. Zhang, Chem. Commun., 2023, 59, 11807 DOI: 10.1039/D3CC04035F

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