Issue 74, 2023

Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Abstract

α-Substituted methylsulfinamide are prepared through the homologation of electrophilic N-sulfinylamines with Li-CHXY reagents. The transformation takes place under full chemocontrol and exhibits good flexibility for preparing both N-aryl and N-alkyl analogues. Various sensitive functionalities can be accommodated on the starting materials, thus documenting a wide reaction scope.

Graphical abstract: Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

Supplementary files

Article information

Article type
Communication
Submitted
12 Jūl. 2023
Accepted
21 Aug. 2023
First published
21 Aug. 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 11065-11068

Highly chemoselective homologative assembly of the α-substituted methylsulfinamide motif from N-sulfinylamines

M. Malik, R. Senatore, D. Castiglione, A. Roller-Prado and V. Pace, Chem. Commun., 2023, 59, 11065 DOI: 10.1039/D3CC03326K

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