Issue 23, 2023

Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Abstract

The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.

Graphical abstract: Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

Supplementary files

Article information

Article type
Communication
Submitted
20 Dec. 2022
Accepted
21 Febr. 2023
First published
22 Febr. 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 3439-3442

Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide

M. Lavayssiere and F. Lamaty, Chem. Commun., 2023, 59, 3439 DOI: 10.1039/D2CC06934B

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements