Issue 14, 2023

Visible-light promoted intramolecular carboamination of alkynes for the synthesis of oxazolidinone-fused isoquinolinones

Abstract

An efficient method for the synthesis of isoquinolinone derivatives via photopromoted carboamination of alkynes is developed. Starting from the readily available propargyl alcohol derivatives, the polycyclic isoquinolinone derivatives could be obtained with good aryl and heterocycle tolerance. Both terminal and alkyl substituted alkynes could be employed. This protocol is operationally easy, and easily conducted on a gram-scale. A possible mechanism involving radical addition and cyclization following aromatization was proposed.

Graphical abstract: Visible-light promoted intramolecular carboamination of alkynes for the synthesis of oxazolidinone-fused isoquinolinones

Supplementary files

Article information

Article type
Communication
Submitted
01 Dec. 2022
Accepted
18 Janv. 2023
First published
19 Janv. 2023

Chem. Commun., 2023,59, 1979-1982

Visible-light promoted intramolecular carboamination of alkynes for the synthesis of oxazolidinone-fused isoquinolinones

Q. Guo, D. Lu, Y. Mao and Z. Lu, Chem. Commun., 2023, 59, 1979 DOI: 10.1039/D2CC06542H

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