Issue 12, 2023

Recent progress in alkynylation with hypervalent iodine reagents

Abstract

Although alkynes are one of the smallest functional groups, they are among the most versatile building blocks for organic chemistry, with applications ranging from biochemistry to material sciences. Alkynylation reactions have traditionally relied on the use of acetylenes as nucleophiles. The discovery and development of ethynyl hypervalent iodine reagents have allowed to greatly expand the transfer of alkynes as electrophilic synthons. In this feature article the progress in the field since 2018 will be presented. After a short introduction on alkynylation reactions and hypervalent iodine reagents, the developments in the synthesis of alkynyl hypervalent iodine reagents will be discussed. Their recent use in base-mediated and transition-metal catalyzed alkynylations will be described. Progress in radical-based alkynylations and atom-economical transformations will then be presented.

Graphical abstract: Recent progress in alkynylation with hypervalent iodine reagents

Article information

Article type
Feature Article
Submitted
14 Nov. 2022
Accepted
23 Dec. 2022
First published
19 Janv. 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 1589-1604

Recent progress in alkynylation with hypervalent iodine reagents

E. Le Du and J. Waser, Chem. Commun., 2023, 59, 1589 DOI: 10.1039/D2CC06168F

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