Issue 9, 2023

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

Abstract

An endoplasmic reticulum targeting NIR fluorescent probe (ERBM) was developed for real-time monitoring of carboxylesterase 1 (CES1) and exhibited excellent ER location in living cell imaging. In addition, ERBM was applied to illustrate the regulation characteristics of CES1 under ER stress and acute liver injury models at the cell and animal level.

Graphical abstract: Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

Supplementary files

Article information

Article type
Communication
Submitted
29 Jūl. 2022
Accepted
12 Dec. 2022
First published
13 Dec. 2022

Chem. Commun., 2023,59, 1145-1148

Rational design of a NIR fluorescent probe for carboxylesterase 1 detection during endoplasmic reticulum stress and drug-induced acute liver injury

C. Han, X. Zhao, X. Huo, Z. Yu, C. Wang, L. Feng, J. Cui, X. Tian and X. Ma, Chem. Commun., 2023, 59, 1145 DOI: 10.1039/D2CC04237A

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