Issue 16, 2023

Personalized demand-responsive biphasic microneedle patch for smart drug administration

Abstract

Many patients, especially those with chronic diseases, would benefit from personalized drugs that could modulate the treatment regimen. Tailored drug delivery via microneedle patches (MNPs) has emerged as a promising technology to address this problem. However, it is still difficult to modulate the treatment regimen in one MNP. Here, multiple treatment regimens were achieved by the same MNP functionalized with modifiable nanocontainers (NCs). The MNPs were biphasic in design, resulting in approximately a twice as high drug loading capacity than that of traditional dissolving MNPs. The drug-loaded NCs could have a zero-order release rate for at least 20 d in vitro. Furthermore, three model MNPs, Type-A (100% drug), Type-B (50% drug and 50% NCs) and Type-C (100% NCs) were generated to simulate various personalized dosing needs. In vivo application of these models could achieve effective therapeutic drug concentrations in the first 12 h and adjusted the duration of effective drug action from 24 h to 96 h and 144 h, respectively, with outstanding biocompatibility. These findings indicate that this device holds significant promise for personalized drug delivery.

Graphical abstract: Personalized demand-responsive biphasic microneedle patch for smart drug administration

  • This article is part of the themed collection: Microneedles

Supplementary files

Article information

Article type
Paper
Submitted
06 Maijs 2023
Accepted
22 Jūn. 2023
First published
23 Jūn. 2023

Biomater. Sci., 2023,11, 5605-5617

Personalized demand-responsive biphasic microneedle patch for smart drug administration

S. Deng, Y. Shuai, S. Zhang, C. Sun, L. Chang, J. Xu, L. Tong, Q. Ji, M. Li, J. Dai and Y. Ju, Biomater. Sci., 2023, 11, 5605 DOI: 10.1039/D3BM00780D

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