Issue 40, 2023

A dihydro-benzo[4,5]imidazo[1,2-c]quinazoline-based probe with aggregation-induced ratiometric emission for the ratiometric fluorescent detection of peroxynitrite in living cells and zebrafish

Abstract

As a significant kind of reactive oxygen species (ROS), peroxynitrite (ONOO) plays an indispensable role in many physiological and pathological processes. This study aimed to synthesize a novel dihydro-benzo[4,5]imidazo[1,2-c]quinazoline-based probe 1 for detecting ONOO. In 99.5% H2O solution, probe 1 displayed a distinct aggregation-induced ratiometric emission (AIRE), and would selectively respond toward ONOOvia a ratiometric fluorescent signal, along with a short response time (<30 s) and ultra-sensitivity (LOD = 17.6 nM). Moreover, the probe was applied for monitoring the concentration fluctuations of ONOO in HeLa cells and zebrafish.

Graphical abstract: A dihydro-benzo[4,5]imidazo[1,2-c]quinazoline-based probe with aggregation-induced ratiometric emission for the ratiometric fluorescent detection of peroxynitrite in living cells and zebrafish

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug. 2023
Accepted
19 Sept. 2023
First published
20 Sept. 2023

Anal. Methods, 2023,15, 5311-5315

A dihydro-benzo[4,5]imidazo[1,2-c]quinazoline-based probe with aggregation-induced ratiometric emission for the ratiometric fluorescent detection of peroxynitrite in living cells and zebrafish

J. Yan, S. Liu, W. Wu, X. Zhao, Y. Fan, Y. Wang and Z. Xu, Anal. Methods, 2023, 15, 5311 DOI: 10.1039/D3AY01416A

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