Issue 16, 2023

A green methodology for the determination of cocaine in camouflaged samples

Abstract

A methodology based on the ultrasound-assisted extraction with ethanol and the dry film attenuated total reflectance infrared spectroscopy (DF-ATR-FTIR) measurement of extracts has been developed for a fast evaluation of non-conventional (“exotic”) solid-sized cocaine samples. The method provides quantitative results in less than three minutes with a limit of detection in the solid sample of 1.6 μg g−1 of cocaine with a variation coefficient lower than 7%. Results found for seized samples of different natures were compared with those obtained by a reference gas chromatography method and the greenness of the whole proposed procedure was evaluated and compared using the analytical eco-scale, green analytical procedure index (GAPI), and analytical greenness metric (AGREE). The green evaluation of the proposed methodology provided green scores by considering different evaluation criteria.

Graphical abstract: A green methodology for the determination of cocaine in camouflaged samples

Supplementary files

Article information

Article type
Paper
Submitted
20 Janv. 2023
Accepted
27 Marts 2023
First published
27 Marts 2023
This article is Open Access
Creative Commons BY-NC license

Anal. Methods, 2023,15, 1969-1978

A green methodology for the determination of cocaine in camouflaged samples

D. Gallart-Mateu, A. Gallardo, S. Garrigues and M. de la Guardia, Anal. Methods, 2023, 15, 1969 DOI: 10.1039/D3AY00113J

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