Issue 41, 2022

Advanced bioactive hydrogels for the treatment of myocardial infarction

Abstract

Myocardial infarction (MI) is the leading cause of cardiovascular disease-related deaths. Local ischemia and cardiomyocyte death lead to a series of pathological remodeling events of the infarcted extracellular matrix (ECM) that are significantly different from normal cardiac tissues. These pathological characteristics have inspired the development of microenvironment-responsive therapeutic strategies for MI. Bioactive hydrogels attract great attention because of their unique physicochemical features to induce specific biological responses upon interacting with cells, ECMs, and signal molecules. They exhibit physicochemical-responsive activities to regulate interactions between hydrogels and the biological system. Many bioactive hydrogels with intelligent properties have been used to repair infarcted myocardium and restore the cardiac function after MI. Current research studies ensure that bioactive hydrogels have a high clinical importance and application prospects. This review summarizes the advances of bioactive hydrogels in the field of on-demand treatment of MI and evaluates their key physicochemical characteristics. A range of bioactive hydrogels and their biomedical applications are discussed in repairing injured hearts and restoring cardiac functions, providing insights into the development of intelligent therapeutic approaches for MI.

Graphical abstract: Advanced bioactive hydrogels for the treatment of myocardial infarction

Article information

Article type
Review Article
Submitted
27 Jūl. 2022
Accepted
23 Sept. 2022
First published
26 Sept. 2022

J. Mater. Chem. B, 2022,10, 8375-8385

Advanced bioactive hydrogels for the treatment of myocardial infarction

Y. Lu, Y. Luo, R. Zhu, X. Huang and S. Bai, J. Mater. Chem. B, 2022, 10, 8375 DOI: 10.1039/D2TB01591A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements