Issue 37, 2022

Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids

Abstract

Bio-applied molecularly imprinted polymers (MIPs) are biomimetic materials with tailor-made synthetic recognition sites, mimicking biological counterparts known for their sensitive and selective analyte detection. MIPs, specifically designed for biomarker analysis within biofluids, have the potential to significantly aid patient diagnostics at the point-of-care, enabling self-health monitoring and management. Recent research in this field, facilitated by the hybridisation of materials science and biology, has developed and utilised a variety of different polymerisation synthesis methods tailored to the bio-application of MIPs. This review evaluates the principles of molecular imprinting for disease diagnostics, including recent progress in integrated MIP-sensor technologies for high-affinity analyte detection in complex biofluids from serum and saliva to cerebrospinal fluid, sweat, urine, nasopharyngeal fluid, and tears. The work highlights the state-of-the-art in the progression of MIP-sensor technologies’ translation into commercially available sensors and their potential contribution to disease detection systems in healthcare settings.

Graphical abstract: Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids

Article information

Article type
Review Article
Submitted
30 Marts 2022
Accepted
20 Jūn. 2022
First published
22 Jūn. 2022
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2022,10, 7418-7449

Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids

Y. L. Mustafa, A. Keirouz and H. S. Leese, J. Mater. Chem. B, 2022, 10, 7418 DOI: 10.1039/D2TB00703G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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