Issue 14, 2022

A biomimetic anti-biofouling coating in nanofluidic channels

Abstract

Non-specific protein adsorption (NPA) is ubiquitous and generally considered a trigger for various biofoulings, adversely affecting diverse fields. Despite many approaches (generally polymer-based) available to combat NPA in a wide range of length scales, suppressing NPA in closed nanoscale spaces of emerging nanodevices such as nanofluidic devices remains a challenge due to the lack of suitable material and methodology to satisfy their ultra-small and closed features. In this study, a biomimetic, hydrosilane-functionalized 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer material, which has tailored molecular characteristics and well-defined surface properties to overcome the challenges in the nanospaces, is elaborately designed and synthesized to form self-assembled, nanoscale, biomimetic coatings, enabling the efficient suppression of NPA in femtoliter-order, closed nanofluidic channels. The approach opens up a new path for exploring a strategic change of anti-biofouling coating from traditional polymer-based methodologies to a monomer-based methodology to overcome the challenge of suppressing NPA in closed nanospaces.

Graphical abstract: A biomimetic anti-biofouling coating in nanofluidic channels

Supplementary files

Article information

Article type
Paper
Submitted
28 Nov. 2021
Accepted
14 Janv. 2022
First published
17 Janv. 2022

J. Mater. Chem. B, 2022,10, 2481-2489

Author version available

A biomimetic anti-biofouling coating in nanofluidic channels

S. Fukuda and Y. Xu, J. Mater. Chem. B, 2022, 10, 2481 DOI: 10.1039/D1TB02627E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements