Issue 14, 2022

Janus membranes with asymmetric cellular adhesion behaviors for regenerating eardrum perforation

Abstract

The tympanic membrane plays an important role in the human hearing system, which is easily perforated under unfavorable conditions, leading to loss of hearing and otitis media. Many autologous materials and artificial materials have been used to repair a perforated tympanic membrane, but these materials sometimes can cause severe hearing loss because of their adhesion to the ossicle during the healing process and the postoperative process. Herein, we report Janus membranes with asymmetric cellular adhesion behaviors for regenerating the eardrum. These Janus membranes are constructed by co-depositing a tannic acid (TA)/3-aminopropyltriethoxysilane (APTES) coating on one surface of the polypropylene microfiltration membrane. Cellular experiments indicate that the Janus membranes have good biocompatibility and asymmetric cellular adhesion properties. The repair of the tympanic membrane perforation experiment and laser Doppler vibrometer (LDV) measurements prove that the hydrophilic surface of Janus membranes repairs perforated eardrums, and meanwhile the hydrophobic surface can avoid adhering to the inner ear tissue for reducing hearing loss. The Janus membranes have good prospects in the treatment of tympanic membrane perforation.

Graphical abstract: Janus membranes with asymmetric cellular adhesion behaviors for regenerating eardrum perforation

Supplementary files

Article information

Article type
Paper
Submitted
05 Nov. 2021
Accepted
25 Janv. 2022
First published
26 Janv. 2022

J. Mater. Chem. B, 2022,10, 2719-2727

Janus membranes with asymmetric cellular adhesion behaviors for regenerating eardrum perforation

Z. Zhang, J. Li, X. Li, C. Zhu, L. Ren, X. Huang, J. Wu, J. Ji and Z. Xu, J. Mater. Chem. B, 2022, 10, 2719 DOI: 10.1039/D1TB02418C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements