Issue 14, 2022

Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces

Abstract

Topical treatments for oral wounds and infections exhibit weak adhesion to wet surfaces which results in short retention duration (6–8 hours), frequent dosing requirement and patient incompatibility. To address these limitations, aqueous composites made of fibrillated bacterial cellulose and photoactive bioadhesives are designed for soft epithelial surfaces. The aqueous composites crosslink upon photocuring within a minute and exhibit a transition from viscous to elastic adhesive hydrogels. The light-cured composites have shear moduli mimicking oral mucosa and other soft tissues. The tunable adhesion strength ranges from 3 to 35 kPa on hydrated tissue-mimicking surfaces (collagen film). The results support the application of bacterial cellulose hydrogel systems for potential treatment of mucosal wounds.

Graphical abstract: Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces

Supplementary files

Article information

Article type
Paper
Submitted
16 Sept. 2021
Accepted
25 Nov. 2021
First published
25 Nov. 2021

J. Mater. Chem. B, 2022,10, 2570-2583

Fibrillated bacterial cellulose liquid carbene bioadhesives for mimicking and bonding oral cavity surfaces

J. Singh, T. W. J. Steele and S. Lim, J. Mater. Chem. B, 2022, 10, 2570 DOI: 10.1039/D1TB02044G

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