Issue 15, 2022

Covalent organic frameworks and multicomponent reactions: an endearing give-and-take relationship

Abstract

Covalent organic frameworks (COFs) are porous and crystalline materials which are assembled from dynamic covalent bonds with two- or three-dimensional (2D or 3D) features. Unlike other polymers, COFs have significant and unique characteristics, including crystallinity, synthetic control, and structurally pre-designable aspects, among others. These notable intrinsic features render them an ideal platform energy conversion and storage, biomedical science, catalysis, sensing, separation, and adsorption applications. Solvothermal, sonochemical, ionothermal, microwave (MW), mechanochemical (MC) and multicomponent reaction (MCR) approaches are synthetic protocols that have been deployed for the construction of these fascinating materials. Herein, the most promising and relevant processing strategies are discussed for the formation of COFs via MCRs, highlighting the most important recent advances and encompassing the properties, characterization techniques, and production methods. A3-coupling, Povarov, Strecker, Groebke–Blackburn–Bienaymé, Debus–Radziszewski, and Doebner reactions are the MCRs that have been reported and summarized for the assembly of COFs. Furthermore, the successful usage of COFs to catalyze MCRs ranging from asymmetric synthesis to simple organic reactions is highlighted and discussed.

Graphical abstract: Covalent organic frameworks and multicomponent reactions: an endearing give-and-take relationship

Article information

Article type
Review Article
Submitted
02 Maijs 2022
Accepted
17 Jūn. 2022
First published
21 Jūn. 2022

Org. Chem. Front., 2022,9, 4178-4191

Covalent organic frameworks and multicomponent reactions: an endearing give-and-take relationship

H. Yazdani, S. E. Hooshmand and R. S. Varma, Org. Chem. Front., 2022, 9, 4178 DOI: 10.1039/D2QO00697A

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