Issue 23, 2022

Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids

Abstract

The interstrand crosslinking and threaded structures of nucleic acids have high potential in oligonucleotide therapeutics, chemical biology, and nanotechnology. For example, properly designed crosslinking structures provide high activity and nuclease resistance for anti-miRNAs. The noncovalent labeling and modification by the threaded structures are useful as new chemical biology tools. Photoreversible crosslinking creates smart materials, such as reversible photoresponsive gels and DNA origami objects. This review introduces the creation of interstrand crosslinking and threaded structures, such as catenanes and rotaxanes, based on hybridization-specific chemical reactions and their functions and perspectives.

Graphical abstract: Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids

Article information

Article type
Review Article
Submitted
23 Marts 2022
Accepted
18 Maijs 2022
First published
19 Maijs 2022

Org. Biomol. Chem., 2022,20, 4699-4708

Author version available

Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids

K. Onizuka, Y. Yamano, A. M. Abdelhady and F. Nagatsugi, Org. Biomol. Chem., 2022, 20, 4699 DOI: 10.1039/D2OB00551D

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