Issue 26, 2022

Copper metal organic framework as natural oxidase mimic for effective killing of Gram-negative and Gram-positive bacteria

Abstract

Nanozymes have been widely studied as substitutes for natural enzymes. However, the delicacy of their structures and their unclear catalytic sites make it difficult to maintain their structural robustness and catalytic durability. By mimicking active catalytic sites of natural enzymes and combining them with distinct channels of metal organic frameworks (MOFs), an active copper mimetic oxidase enzyme (Cu-MOF) was designed and synthesized with good structure and clear catalytic sites for improvement in catalytic activity. The Cu-MOFs showed excellent oxidase-like activity with a low Km of 1.09 mM and exogenous ROS generation capacity. The Cu-MOFs exhibited antibacterial efficacy at a low concentration of 12.5 μg mL−1 by an oxidative stress response. These Cu-MOFs with their simple design and effective oxidase mimicking show attractive application prospects in the field of antibacterial and enzyme catalysis.

Graphical abstract: Copper metal organic framework as natural oxidase mimic for effective killing of Gram-negative and Gram-positive bacteria

Supplementary files

Article information

Article type
Paper
Submitted
26 Marts 2022
Accepted
02 Jūn. 2022
First published
08 Jūn. 2022

Nanoscale, 2022,14, 9474-9484

Copper metal organic framework as natural oxidase mimic for effective killing of Gram-negative and Gram-positive bacteria

Z. Mao, J. Chen, Y. Wang, J. Xia, Y. Zhang, W. Zhang, H. Zhu, X. Hu and H. Chen, Nanoscale, 2022, 14, 9474 DOI: 10.1039/D2NR01673G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements