Issue 2, 2022

Biology-guided engineering of bioelectrical interfaces

Abstract

Bioelectrical interfaces that bridge biotic and abiotic systems have heightened the ability to monitor, understand, and manipulate biological systems and are catalyzing profound progress in neuroscience research, treatments for heart failure, and microbial energy systems. With advances in nanotechnology, bifunctional and high-density devices with tailored structural designs are being developed to enable multiplexed recording or stimulation across multiple spatial and temporal scales with resolution down to millisecond–nanometer interfaces, enabling efficient and effective communication with intracellular electrical activities in a relatively noninvasive and biocompatible manner. This review provides an overview of how biological systems guide the design, engineering, and implementation of bioelectrical interfaces for biomedical applications. We investigate recent advances in bioelectrical interfaces for applications in nervous, cardiac, and microbial systems, and we also discuss the outlook of state-of-the-art biology-guided bioelectrical interfaces with high biocompatibility, extended long-term stability, and integrated system functionality for potential clinical usage.

Graphical abstract: Biology-guided engineering of bioelectrical interfaces

Article information

Article type
Review Article
Submitted
13 Okt. 2021
Accepted
29 Nov. 2021
First published
14 Dec. 2021

Nanoscale Horiz., 2022,7, 94-111

Author version available

Biology-guided engineering of bioelectrical interfaces

B. A. Miao, L. Meng and B. Tian, Nanoscale Horiz., 2022, 7, 94 DOI: 10.1039/D1NH00538C

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