Issue 9, 2022

Differential copper-guided architectures of amyloid β peptidomimetics modulate oxidation states and catalysis

Abstract

Orchestration of differential architectures of designer peptidomimetics that modulate metal oxidation states to perform multiple chemical transformations remains a challenge. Cu-chelation and self-assembly properties of amyloid β (Aβ14-23) peptide were tuned by the incorporation of cyclic dipeptide (CDP) and pyrene (Py) as the assembly directing and reporting units, respectively. We explore the molecular architectonics of Aβ14-23 derived peptidomimetics (AkdNMCPy) to form differential architectures that stabilize distinct Cu oxidation states. The fibrillar self-assembly of AkdNMCPy is modulated to form nanosheets by the one-off addition of CuII. Notably, the serial addition of CuII resulted in the formation of micelle-like core–shell architectures. The micelle-like and nanosheet architectures were found to differentially stabilize CuII and CuI states and catalyze tandem oxidative-hydrolysis and alkyne–azide cycloaddition reactions, respectively.

Graphical abstract: Differential copper-guided architectures of amyloid β peptidomimetics modulate oxidation states and catalysis

Supplementary files

Article information

Article type
Paper
Submitted
15 Marts 2022
Accepted
30 Marts 2022
First published
31 Marts 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 2196-2200

Differential copper-guided architectures of amyloid β peptidomimetics modulate oxidation states and catalysis

D. Ghosh, M. Konar, T. Mondal and T. Govindaraju, Nanoscale Adv., 2022, 4, 2196 DOI: 10.1039/D2NA00161F

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